脂质立方液晶纳米粒的研究进展及其在经皮给药系统中的应用

刘丽丽, 陈谢谢, 陈家乐, 金晨, 朱卫丰, 陈丽华, 盛望鹏

中国药学杂志 ›› 2017, Vol. 52 ›› Issue (12) : 1005-1010.

PDF(1512 KB)
PDF(1512 KB)
中国药学杂志 ›› 2017, Vol. 52 ›› Issue (12) : 1005-1010. DOI: 10.11669/cpj.2017.12.002
综述

脂质立方液晶纳米粒的研究进展及其在经皮给药系统中的应用

  • 刘丽丽1,2, 陈谢谢1, 陈家乐1, 金晨1, 朱卫丰1, 陈丽华1*, 盛望鹏3*
作者信息 +

Recent Advances and Transdermal Application of Cubosomes

  • LIU Li-li1,2, CHEN Xie-xie1, CHEN Jia-le1, JING Chen1, ZHU Wei-feng1, CHEN Li-hua1*, SHENG Wang-peng3*
Author information +
文章历史 +

摘要

本文从脂质立方液晶纳米粒的结构特点、常见载体材料、制备及表征等方面,重点对脂质立方液晶纳米粒在经皮给药中的应用进行归纳综述,分析其作为经皮给药药物载体的优势、前景及存在的问题,为进一步脂质立方液晶纳米粒经皮给药制剂的开发提供参考。

Abstract

This review introduced the structural characteristics, drug carrier materials,preparation and exosyndrome of cubosomes. The authors mainly analyzed the advantages, prospect and existing problems of cubosomes as apotential drug delivery system for transdermal administration to provide a reference for further development of cubosomes as a drug delivery system for transdermal administration.

关键词

脂质立方液晶纳米粒 / 药物载体 / 经皮给药

Key words

cubosome / drug delivery system / transdermal administration

引用本文

导出引用
刘丽丽, 陈谢谢, 陈家乐, 金晨, 朱卫丰, 陈丽华, 盛望鹏. 脂质立方液晶纳米粒的研究进展及其在经皮给药系统中的应用[J]. 中国药学杂志, 2017, 52(12): 1005-1010 https://doi.org/10.11669/cpj.2017.12.002
LIU Li-li, CHEN Xie-xie, CHEN Jia-le, JING Chen, ZHU Wei-feng, CHEN Li-hua, SHENG Wang-peng. Recent Advances and Transdermal Application of Cubosomes[J]. Chinese Pharmaceutical Journal, 2017, 52(12): 1005-1010 https://doi.org/10.11669/cpj.2017.12.002
中图分类号: R944   

参考文献

[1]LUZZATI V, TARDIEU A, GULIK-KRZYWIEKI T, et al. Structure of the cubic phases of lipid-water systems [J]. Nature,1968,220(5166):485-488.[2]TARDIEU A,LUZZATI V. A novelcubicphase-a cage-like network of rods with enclosed spherical micelles [J]. Biochim Biophys Acta, 1970, 219(1):11-17.[3]LARSSON K,FONTELL K,KROG N.Structural relationshipsbetween lamellar cubic and hexagonal phases in monoglyceride-watersystems. Possibility of cubic structures in biological systems [J]. Chem Phys Lipids, 1980, 7(4):321-328.[4]SHAH J C, SADHALE Y, CHILUKURID M.Cubic phase gels as drug delivery systems [J]. Adv Drug Deliv Rev, 2001,47 (2):229-250.[5]PAN X, HAN K, PENG X, et al.Nanostructured cubosomes asadvanced drug delivery system[J]. Curr Pharm Des, 2013, 19(35):6290-6297.[6]RIZWAN S B, BOYD B J, RADES T, et al.Bicontinuous cubicliquid crystals as sustained delivery systems for peptides and proteins[J]. Expert Opin Drug Deliv, 2010, 7(10):1133-1144.[7]WRLE G, SIEKMANN B, BUNJES H.Effect of drug loadinon the transformation of vesicular into cubic nanoparticles during heat treatment of aqueous monoolein/poloxamer dispersions[J]. Eur J Pharm Biopharm, 2006, 63(2):128-133.[8]CHEN X, FU G Y, HU Q, et al. Quality evaluation of fluconazole-loaded cubic ohase gels[J]. Mil Med Sci(军事医学),2015,39(12):948-951.[9]VINOD K R, SRAVYA K, SANDHYA S, et al. Tailoring active compounds across biological membranes by cubosomal technology:an updated review[J]. Chin Pharm Sci, 2013, 22 (4):303-313.[10]ZHOU Y F, PENG X S. In vitro study on liquid crystalline material of glycerol monoolein[J]. China Med Her(中国医药导报),2010,7(10):22-24. [11]HINTON T M, GRUSCHE F, ACHARYA D, et al. Bicontinuous cubic phase nanoparticle lipid chemistry affects toxicity in cultured cells[J]. Toxicol Res, 2014, 3(1):11-22.[12]GUO C, WANG J, CAO F, et al. Lyotropic liquid crystal systems in drug delivery[J]. Drug Discov Today, 2010,15(23-24):1032-1040.[13]MORSI N M, ABDELBARY G M, AHMED M A. Silver sulfadiazine based cubosome hydrogels for topical treatment of burns: development and in vitro/in vivo characterization[J]. Eur J Pharm Sci,2014,86(2):178-189.[14]LIAN R, LU Y, QI J, et al. Silymaringlycerylmonooleate/poloxamer 407 liquid crystalline matrices:physical characterization and enhanced oral bioavailability[J]. AAPS Pharm Sci Tech, 2011,12(4):1-7.[15]YAMADA K, YAMASHITA J, TODO H, et al.Preparation andevaluation of liquid-crystal formulations with skin-permeation-enhancing abilities for entrapped drugs[J].J Oleo Sci,2011,60(1):31-40.[16]WANG Z N,ZHENG L Q.Progress in cubic phase of lipid liquidcrystal as drug delivery system[J]. Prog Chem,2005,17 (3):417-422.[17]POLYZOS A, ALDERTON M R, DAWSON R M, et al. Biofunctionalized surfactant mesophases as polyvalent inhibitors of cholera toxin[J]. Bioconjug Chem,2007, 18(5):1442-1449.[18]ZHENG M, WANG Z, LIU F, et al. Study on the microstructure and rheological property of fish oil lyotropic liquid crystal[J]. Colloid Surf A:Physicochem Eng Aspects, 2011, 385(1-3):47-54.[19]WORLE G, SIEKMANN B, KOCH M H J, et al. Transformation of vesicular into cubic nanoparticles by autoclaving of aqueous monoolein/poloxamer dispersions[J]. Eur J Pharm Sci,2006, 27(1):44-53.[20]LUZZATI V. X-ray diffraction studies of lipid-water systems[J]. Biological Membranes,1968, 1:71-123.[21]RIZWAN S, DONG Y D, BOYD B, et al. Characterisation of bicontinuous cubic liquid crystalline systems of phytantriol and water using cryo field emission scanning electron microscopy (cryoFESEM) [J]. Micron,2007, 38(5):478-485.[22]GUSTAFSSON J, LJUSBERG-WAHREN H, ALMGREN M, et al. Cubic lipid-water phase dispersed into submicron particles[J]. Langmuir ,1996, 12(20):4611-4613.[23]SAGALOWICZ L, MEZZENGA R, LESER M E. Investigating reversed liquid crystalline mesophases[J]. Curr Opin Colloid Interface Sci, 2006,11(4):224-229.[24]KUNTSCHE J, HORST J C, BUNJES H. Cryogenic transmission electron microscopy (cryo-TEM) for studying the morphology of colloidal drug delivery systems[J]. Int J Pharm,2011,47(1-2):229-250.[25]CHANG C M, BODMEIER R. Swelling of and drug release frommonoglyceride-based drug delivery systems [J]. J Pharm Sci,1997,86(6):747-752.[26]HUNDEKAR Y R, SABOJI J K, PATIL S M. Preparation and evaluation of diclofenac sodium cubosomes for percutaneous administration[J]. World J Pharm Pharm Sci,2014,3(1):523-539.[27]ESPOSITO E, CORTESI R, DRECHSLER M. Cubosome dispersions as delivery systems for percutaneous administration of indomethacin [J]. Pharm Res, 2005,22(12):2063-2173.[28]PENG X S, ZHOU Y F, HAN K, et al.Characterization of cubosomes as a targeted and sustained transdermaldelivery system for capsaicin[J]. Drug Des Devel Ther, 2015,9:4209-4218.[29]PRAJAPATI V, JAIN A, JAIN R. Treatment of cutaneous candidiasis through fluconazole encapsulated cubosomes[J]. Drug Deliv Transl Res, 2014,4(5):400-408.[30]MORSI N M, ABDELBARY G A, AHMED M A. Silver sulfadiazine based cubosome hydrogels for topical treatmentof burns:development and in vitro/in vivo characterization[J]. Eur J Pharm Biopharm, 2014, 86(2):178-189.[31]LI J C, ZHU N, ZHU J X, et al. Self-assembled cubic liquid crystalline nanoparticles for transdermal delivery of paeonol[J]. Med Sci Monit, 2015, 21:3298-3310.[32]KWON T K, KIM J C. In vitro skin permeation and anti-atopic efficacy of lipid nanocarrierscontaining water soluble extracts of houttuyniacordata[J]. Drug Dev Ind Pharm, 2014,40(10):1350-1357.[33]JAIN V, JAIN N K.Cubosomes:a tool for percutaneous administration of an antifungal agent[C]. International Conference on Bioencapsulation- Porto, Portugal - October 1-2, 2010.[34]RATTANAPAK T, BIRCHALL J, YOUNG K, et al. Transcutaneous immunization using microneedles and cubosomes:mechanistic investigations using optical coherence tomography and two-photon microscopy[J]. J Controlled Release, 2013, 172(3):894-903.[35]RATTANAPAK T, YOUNG K, RADES T, et al. Comparative study of liposomes, transfersomes, ethosomesandcubosomes for transcutaneous immunisation:characterisation and in vitro skin penetration[J]. J Pharm Pharmacol, 2012,64(11):1560-1569.[36]SHERIF S, BENDAS E R, BADAWY S, et al. The clinical efficacy of cosmeceutical application of liquid crystalline nanostructured dispersions of alpha lipoic acid as anti-wrinkle[J]. Eur J Pharm Biopharm, 2014, 86(2):251-259.[37]KWON T K, KIM J C. Preparation and in vitro skin permeation of cubosomes containing hinokitiol [J]. J Dispers Sci Technol, 2010, 31(7):1004-1009.[38]SEO S R, KANG G, HA J W, et al. In vivo hair growth-promoting efficacies of herbal extracts and their cubosomal suspensions[J]. J Ind Eng Chem, 2013,19(4):1331-1339.[39]MADHESWARAN T,BASKARAN R,THAPA R K. Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery[J]. Pharm Sci Tech,2013,14(1):45-52.[40]ESPOSITO E, RAVANI L, MARIANI P, et al. Effect of nanostructured lipid vehicles on percutaneous absorption of curcumin[J]. Eur J Pharm Biopharm,2014,86(2):121-132.

基金

国家自然科学基金资助项目(81460606);江西省自然科学基金资助项目(20142BAB205080);海南省自然科学基金资助项目(20168365);江西省卫生计生委中医药科研计划(2014A59)
PDF(1512 KB)

Accesses

Citation

Detail

段落导航
相关文章

/